Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats
| Autor: | Zhao Junwei, Long Xu, Limeng Wang, Xiujie Pan, Jianping Xie, Xing-yu Liu, Xiang Li, Mao-xiang Zhu, Zhi-hua Yang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Inflammation Toxicology 03 medical and health sciences chemistry.chemical_compound Immune system T-Lymphocyte Subsets In vivo Internal medicine Edema Macrophages Alveolar medicine Animals Humans Rats Wistar Crotonaldehyde Air Pollutants Aldehydes Phagocytes medicine.diagnostic_test Cell counting In vitro 030104 developmental biology Endocrinology Bronchoalveolar lavage Immune System Diseases chemistry Acute Disease medicine.symptom Bronchoalveolar Lavage Fluid |
| Zdroj: | The Journal of Toxicological Sciences. 43:33-44 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.43.33 |
| Popis: | Crotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammation, and acute respiratory distress syndrome in the lungs. However, the effects of crotonaldehyde on the immune system have not been reported. In the present study, 6-8 weeks old male Wistar rats were exposed to crotonaldehyde by intratracheal instillation at doses of 4, 8, and 16 μL/kg body weight (b.w.). The general damage in the animals was investigated; the cell counting and the biochemical analysis in the peripheral blood were tested. Furthermore, we investigated the functions of alveolar macrophages (AMs), the alterations of the T-lymphocyte subsets, and the cell composition in the bronchoalveolar lavage fluid (BALF). We found that the activities of the animals were changed after exposure to crotonaldehyde, the cellular ratios and the biochemical components in the peripheral blood were altered, the ratio of mononuclear phagocytes decreased, and the ratios of lymphocytes and granulocytes elevated significantly in BALF. Meanwhile, crotonaldehyde altered the ratio of the T-lymphocyte subsets, and the phagocytic rates and indices of AMs increased obviously. In conclusion, crotonaldehyde induces dysfunction of immune system in male Wistar rats. |
| Databáze: | OpenAIRE |
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