Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study
| Autor: | Scott Ian Kay Semple, Timothy J. Kendall, Natasha McDonald, Peter J Eddowes, Stefan G. Hubscher, Stella Kin, Rachel M. Brown, Desley Neil, James Hodson, Catherine Kelly, Nigel P. Davies, Miranda Phillips, Gideon M. Hirschfield, Amy H. Herlihy, Jonathan A. Fallowfield |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Liver Cirrhosis Male Biopsy Iron lcsh:Medicine Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Liver disease 0302 clinical medicine medicine Humans Prospective Studies Prospective cohort study lcsh:Science Multiparametric Magnetic Resonance Imaging Reproducibility Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Gold standard (test) Middle Aged medicine.disease Magnetic Resonance Imaging 3. Good health Fatty Liver Cross-Sectional Studies Liver 030211 gastroenterology & hepatology Female lcsh:Q Steatosis Transient elastography Nuclear medicine business |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) Scientific Reports McDonald, N, Eddowes, P J, Hodson, J, Semple, S I K, Davies, N P, Kelly, C J, Kin, S, Phillips, M, Herlihy, A H, Kendall, T J, Brown, R M, Neil, D A H, Hübscher, S G, Hirschfield, G M & Fallowfield, J A 2018, ' Multiparametric magnetic resonance imaging for quantitation of liver disease : a two-centre cross-sectional observational study ', Scientific Reports, vol. 8, no. 1, pp. 9189 . https://doi.org/10.1038/s41598-018-27560-5 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-27560-5 |
| Popis: | LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers. Iron-corrected T1 (cT1), TE, and ELF demonstrated a positive correlation with hepatic collagen proportionate area (all p MultiScan showed excellent test/re-test reliability (coefficients of variation ranging from 1.4% to 2.8% for cT1). Overall failure rates for LiverMultiScan, ELF and TE were 4.3%, 1.9% and 15%, respectively. LiverMultiScan is an emerging point-of-care diagnostic tool that is comparable with the established non-invasive tests for assessment of liver fibrosis, whilst at the same time offering a superior technical success rate and contemporaneous measurement of liver steatosis and iron accumulation. |
| Databáze: | OpenAIRE |
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