Maternal diet quality before pregnancy and risk of childhood leukaemia
Autor: | Gladys Block, Steve Selvin, Cecilia Fu, Amanda W. Singer, Catherine Metayer, Suzan L. Carmichael |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male Risk Vitamin Pediatrics medicine.medical_specialty Adolescent Nutritional Status Medicine (miscellaneous) California Fetal Development Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Epidemiology Humans Medicine 030212 general & internal medicine Child Fetus Nutrition and Dietetics Prenatal nutrition business.industry Infant Maternal Nutritional Physiological Phenomena Vitamins Precursor Cell Lymphoblastic Leukemia-Lymphoma Hospitals Pediatric medicine.disease Diet Childhood leukaemia Leukemia Myeloid Acute chemistry Quartile Diet quality Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Dietary Supplements Patient Compliance Female Self Report Diet Healthy business |
Zdroj: | British Journal of Nutrition. 116:1469-1478 |
ISSN: | 1475-2662 0007-1145 |
Popis: | Previous studies on maternal nutrition and childhood leukaemia risk have focused on the role of specific nutrients such as folate and have not considered broader measures of diet quality, which may better capture intake of diverse nutrients known to impact fetal development. We examined the relationship between maternal diet quality before pregnancy, as summarised by a diet quality index, and risk of childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in a case–control study in California. Dietary intake in the year before pregnancy was assessed using FFQ in 681 ALL cases, 103 AML cases and 1076 matched controls. Conditional logistic regression was used to estimate OR and 95 % CI for diet quality continuous score and quartiles (Q1–Q4). Higher maternal diet quality score was associated with reduced risk of ALL (OR 0·66; 95 % CI 0·47, 0·93 for Q4v.Q1) and possibly AML (OR 0·42; 95 % CI 0·15, 1·15 for Q4v.Q1). No single index component appeared to account for the association. The association of maternal diet quality with risk of ALL was stronger in children diagnosed under the age of 5 years and in children of women who did not report using vitamin supplements before pregnancy. These findings suggest that the joint effects of many dietary components may be important in influencing childhood leukaemia risk. |
Databáze: | OpenAIRE |
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