Comparative proteomics reveals anticancer compounds from Lansium domesticum against NSCLC cells target mitochondrial processes

Autor: Michael Russelle Alvarez, Florence De Juan, Qingwen Zhou, Ian Ken D. Dimzon, Sheryl Joyce Grijaldo, Sean Sunga, Francisco Heralde, Carlito B. Lebrilla, Gladys Cherisse Completo, Ruel C. Nacario
Rok vydání: 2023
Předmět:
Zdroj: Cell Biochemistry and Function. 41:166-176
ISSN: 1099-0844
0263-6484
Popis: Lansium domesticum is identified as a potential source of anticancer compounds. However, there are minimal studies on its anti-lung cancer properties as well as its mechanism of action. Here, we show the specificity of lanzones hexane (LH) leaf extracts to non-small cell lung cancer cells (A549) compared to normal lung fibroblast cells (CCD19-Lu) and normal epithelial prostate cells (PNT2). Subsequent bioassay-guided fractionation of the hexane leaf extracts identified two bioactive fractions with IC
Databáze: OpenAIRE
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