Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?
| Autor: | Kassandra Lanchais, Anne Tournadre, Frédéric Capel |
|---|---|
| Přispěvatelé: | Capel, Frédéric, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), Pack Ambition Recherche Auvergne Rhône Alpes, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
rheumatoid arthritis
0301 basic medicine Sarcopenia medicine.medical_specialty muscle lcsh:TX341-641 Review Arthritis Rheumatoid lipids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Fatty Acids Omega-3 medicine sarcopénie inflammation omega 3 Humans Food and Nutrition 030203 arthritis & rheumatology Nutrition and Dietetics Cholesterol business.industry Lipid metabolism medicine.disease Muscle atrophy cardiovascular diseases 3. Good health 030104 developmental biology Endocrinology chemistry Lipotoxicity Alimentation et Nutrition Metabolic syndrome medicine.symptom business lcsh:Nutrition. Foods and food supply [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science Lipoprotein |
| Zdroj: | Nutrients 1 (12), . (2020) Nutrients Nutrients, 2020, 12 (1), ⟨10.3390/nu12010223⟩ Nutrients, MDPI, 2020, 12 (1), ⟨10.3390/nu12010223⟩ Nutrients, Vol 12, Iss 1, p 223 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12010223⟩ |
| Popis: | This article belongs to the Special Issue Polyunsaturated Fatty Acids Intake and Human Health; Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a high prevalence of death due to cardiometabolic diseases. As observed during the aging process, several comorbidities, such as cardiovascular disorders (CVD), insulin resistance, metabolic syndrome and sarcopenia, are frequently associated to RA. These abnormalities could be closely linked to alterations in lipid metabolism. Indeed, RA patients exhibit a lipid paradox, defined by reduced levels of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol whereas the CVD risk is increased. Moreover, the accumulation of toxic lipid mediators (i.e., lipotoxicity) in skeletal muscles can induce mitochondrial dysfunctions and insulin resistance, which are both crucial determinants of CVD and sarcopenia. The prevention or reversion of these biological perturbations in RA patients could contribute to the maintenance of muscle health and thus be protective against the increased risk for cardiometabolic diseases, dysmobility and mortality. Yet, several studies have shown that omega 3 fatty acids (FA) could prevent the development of RA, improve muscle metabolism and limit muscle atrophy in obese and insulin-resistant subjects. Thereby, dietary supplementation with omega 3 FA should be a promising strategy to counteract muscle lipotoxicity and for the prevention of comorbidities in RA patients. |
| Databáze: | OpenAIRE |
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