Ex vivo 1H MR spectroscopy and histology after experimental chronic spinal cord compression
| Autor: | Matthias Setzer, Stephan Duetzmann, Gerhard Marquardt, Ulrich Pilatus, Volker Seifert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Histology Neurological examination medicine.disease Spinal cord 03 medical and health sciences Myelopathy 0302 clinical medicine medicine.anatomical_structure Neuroimaging Spinal cord compression medicine Orthopedics and Sports Medicine Surgery Original Study 030212 general & internal medicine business 030217 neurology & neurosurgery Ex vivo |
| Popis: | Background: Proton magnetic resonance imaging (MRS) is used increasingly to image the spinal cord in compressive cervical myelopathy (CSM). However, detailed analyses of the underlying histomorphological changes leading to MRS alterations are still lacking. The aim of our study was to correlate neuroimaging and neuropathologic alterations in a rabbit myelopathy model. Methods: Chronic spinal cord compression was induced in a rabbit model (n=16) allowing for a gradual 270° compression of the spinal cord. Spinal cord compression core areas were divided into two samples for (A) 1H MRS and (B) histopathological analyses. Postoperatively the animals underwent a neurological examination twice a day and outcome was categorized in pattern of injury and amount of recovery. Results: Three groups were observed and categorized: (I) animals with severe deficits and no or minimal recovery; (II) animals with severe deficits and complete or almost complete recovery; (III) animals with mild to moderate deficits and a complete recovery. Significant differences in the lesioned spinal cords between the different recovery groups were found for N-acetyl-aspartate and choline. NAA/Cr was detected significantly (P Conclusions: MR spectroscopy (MRS) may be helpful for clinicians in improving the prognostic accuracy in cervical myelopathies since this method nicely reflects the extent and severity of spinal cord damage. |
| Databáze: | OpenAIRE |
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