Evaluation of therapeutically induced hypertension in patients with delayed cerebral vasospasm by xenon-enhanced computed tomography
| Autor: | Hajime Touho, Hideyuki Ohnishi, Jun Karasawa, Keisuke Yamada, Hisashi Shishido, Keiji Shibamoto |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Subarachnoid hemorrhage Xenon medicine.medical_treatment Dopamine Central nervous system Blood Pressure Cerebral vasospasm medicine Humans Craniotomy Aged Aged 80 and over business.industry Vasospasm Blood flow Middle Aged medicine.disease medicine.anatomical_structure Cerebral blood flow Ischemic Attack Transient Anesthesia Cerebrovascular Circulation Cardiovascular agent cardiovascular system Surgery Neurology (clinical) business Tomography X-Ray Computed circulatory and respiratory physiology |
| Zdroj: | Neurologia medico-chirurgica. 32(9) |
| ISSN: | 0470-8105 |
| Popis: | Serial cerebral blood flow (CBF) measurements were made with stable xenon-enhanced computed tomography in 20 patients with angiographically confirmed ruptured intracranial aneurysms, before and during induced hypertension with continuous infusion of dopamine. All patients showed angiographic vasospasm during their course. Twelve patients without symptomatic vasospasm (Group 1) had the lowest hemispheric CBF on the craniotomy side of 31.6 +/- 6.8 ml/100 gm/min on days 4-9 (control value, 40.1 +/- 2.0 ml/100 gm/min), while the other eight patients with symptomatic vasospasm (Group 2) had the lowest hemispheric CBF on the craniotomy side of 25.0 +/- 7.6 ml/100 gm/min on days 10-14. The critical hemispheric CBF inducing neurological deficits was about 20 ml/100 gm/min in Group 2. Dysautoregulation was usually present in Groups 1 and 2, but therapeutically induced hypertension could reverse the delayed neurological deficits, if begun early at the stage of delayed vasospasm. |
| Databáze: | OpenAIRE |
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