Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank

Autor:	Maki Inoue-Choi, Yesenia Ramirez, Marilyn C. Cornelis, Amy Berrington de González, Neal D. Freedman, Erikka Loftfield
Rok vydání:	2022
Předmět:	Male Tea Myocardial Ischemia General Medicine Coffee United Kingdom Stroke Cardiovascular Diseases Risk Factors Caffeine Cause of Death Internal Medicine Humans Female Prospective Studies Biological Specimen Banks Follow-Up Studies
Zdroj:	Annals of Internal Medicine. 175:1201-1211
ISSN:	1539-3704 0003-4819
DOI:	10.7326/m22-0041
Popis:	Tea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.To evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.Prospective cohort study.The UK Biobank.498 043 men and women aged 40 to 69 years who completed the baseline touchscreen questionnaire from 2006 to 2010.Self-reported tea intake and mortality from all causes and leading causes of death, including cancer, all cardiovascular disease (CVD), ischemic heart disease, stroke, and respiratory disease.During a median follow-up of 11.2 years, higher tea intake was modestly associated with lower all-cause mortality risk among those who drank 2 or more cups per day. Relative to no tea drinking, the hazard ratios (95% CIs) for participants drinking 1 or fewer, 2 to 3, 4 to 5, 6 to 7, 8 to 9, and 10 or more cups per day were 0.95 (95% CI, 0.91 to 1.00), 0.87 (CI, 0.84 to 0.91), 0.88 (CI, 0.84 to 0.91), 0.88 (CI, 0.84 to 0.92), 0.91 (CI, 0.86 to 0.97), and 0.89 (CI, 0.84 to 0.95), respectively. Inverse associations were seen for mortality from all CVD, ischemic heart disease, and stroke. Findings were similar regardless of whether participants also drank coffee or not or of genetic score for caffeine metabolism.Potentially important aspects of tea intake (for example, portion size and tea strength) were not assessed.Higher tea intake was associated with lower mortality risk among those drinking 2 or more cups per day, regardless of genetic variation in caffeine metabolism. These findings suggest that tea, even at higher levels of intake, can be part of a healthy diet.National Cancer Institute Intramural Research Program.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac3610f6036bb92e65b127815b6b2f0 https://doi.org/10.7326/m22-0041 Zobrazit plný text záznamu