Short-term Menhaden Oil Rich Diet Changes Renal Lipid Profile in Acute Kidney Injury
| Autor: | Valeria Denninghoff, Georgina P. Ossani, Alberto J. Monserrat, Raúl Eduardo Uicich, Ana Uceda, Maria L. Diaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
CIENCIAS MÉDICAS Y DE LA SALUD Docosahexaenoic Acids General Chemical Engineering Myristic acid Weanling Kidney Myristic Acid Choline chemistry.chemical_compound Fish Oils Fatty Acids Omega-3 Menhaden Oil medicine Animals Plant Oils Food science Rats Wistar medicine.diagnostic_test Fatty Acids Otras Medicina Básica Acute kidney injury Kidney metabolism General Medicine General Chemistry purl.org/becyt/ford/3.1 [https] Acute Kidney Injury Lipid Metabolism medicine.disease Choline Deficiency Medicina Básica Disease Models Animal Vegetable oil Eicosapentaenoic Acid Biochemistry chemistry Docosahexaenoic acid purl.org/becyt/ford/3 [https] Lipid profile |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Weanling male Wistar rats fed a choline-deficient diet develop acute kidney injury. Menhaden oil, which is a very important source of omega-3 fatty acids, has a notorious protective effect. The mechanism of this protection is unknown; one possibility could be that menhaden oil changes renal lipid profile, with an impact on the functions of biological membranes. The aim of this work was to study the renal lipid profile in rats fed a choline-deficient diet with menhaden oil or vegetable oil as lipids. Rats were divided into 4 groups and fed four different diets for 7 days: choline-deficient or choline-supplemented diets with corn and hydrogenated oils or menhaden oil. Serum homocysteine, vitamin B12, and folic acid were analyzed. Renal lipid profile, as well as the fatty acid composition of the three oils, was measured. Choline-deficient rats fed vegetable oils showed renal cortical necrosis. Renal omega-6 fatty acids were higher in rats fed a choline-deficient diet and a choline-supplemented diet with vegetable oils, while renal omega-3 fatty acids were higher in rats fed a choline-deficient diet and a choline-supplemented diet with menhaden oil. Rats fed menhaden oil diets had higher levels of renal eicosapentaenoic and docosahexaenoic acids. Renal myristic acid was increased in rats fed menhaden oil. The lipid renal profile varied quickly according to the type of oil contented in the diet. Fil: Ossani, Georgina Paula. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Denninghoff, Valeria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina Fil: Uceda, Ana Margarita. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina Fil: Díaz, Maria L.. Hospital Británico de Buenos Aires; Argentina Fil: Uicich, Raúl. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Monserrat, Alberto Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología. Centro de Patología Experimental; Argentina |
| Databáze: | OpenAIRE |
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