Relationship between Vitamin D Binding Protein and Aspirin Resistance in Coronary Ischemic Patients: A Proteomic Study
| Autor: | Carlos Macaya, Sergio Alonso-Orgaz, Daniel Sacristán, Miguel Fernández-Arquero, Petra J. Mateos-Cáceres, Antonio J. López-Farré, Teresa Pérez de Prada, Luis Azcona, and Antonio Fernández-Ortiz Md, Esther Bernardo |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Proteomics Fibrinogen-gamma chain Platelet Aggregation Proteome Vitamin D-binding protein Drug Resistance Coronary Disease Pharmacology Biochemistry Thromboxane A2 chemistry.chemical_compound medicine Humans Protein Isoforms Electrophoresis Gel Two-Dimensional Platelet Aged Aspirin biology business.industry Vitamin D-Binding Protein Haptoglobin Blood Proteins General Chemistry Middle Aged Blood proteins digestive system diseases surgical procedures operative chemistry Immunology biology.protein Platelet aggregation inhibitor Female business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of Proteome Research. 6:2481-2487 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr060600i |
| Popis: | Our aim was to analyze the plasma proteome in aspirin (acetylsalicylic acid [ASA])-sensitive and ASA-resistant coronary ischemic patients. Plasma from 19 ASA-sensitive and 19 ASA-resistant patients was analyzed. For the proteomic study, two-dimensional electrophoresis was performed. The expression of one isotype of the fibrinogen gamma chain and three isotypes of haptoglobin was increased in ASA-resistant patients. Three vitamin D binding protein isotypes were increased in ASA-resistant patients. In vitro incubation of vitamin D binding protein (DBP) with blood from healthy volunteers reduced the inhibitory effect of ASA on thromboxane A2 production. DBP may be a new regulator of the inhibitory effect of ASA on platelets. |
| Databáze: | OpenAIRE |
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