Protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification: Rabbit model
| Autor: | Shmuel Ben-Eliahu, Asher Milstein, Kfir Tal, Nati Ezov, Tal Levin-Harrus, Guy Kleinmann |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Endothelium medicine.medical_treatment Sodium hyaluronate Cell Count Group A Group B chemistry.chemical_compound Ophthalmology Cornea medicine Animals Hyaluronic Acid Phacoemulsification Lagomorpha Viscosupplements biology business.industry Chondroitin Sulfates Endothelium Corneal Corneal Endothelial Cell Loss biology.organism_classification Sensory Systems Endothelial stem cell Drug Combinations medicine.anatomical_structure chemistry Models Animal Surgery Rabbits Ophthalmic Solutions business |
| Zdroj: | Journal of Cataract and Refractive Surgery. 36:1972-1975 |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/j.jcrs.2010.05.023 |
| Popis: | Purpose To evaluate the protective effect of different ophthalmic viscosurgical devices on corneal endothelial cells during phacoemulsification in a rabbit model. Setting Harlan Biotech Israel and Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel. Design Experimental study. Methods Rabbit eyes were randomly assigned to 3 equally sized groups. Endothelial cell counts were performed in all eyes before initiation of the study. The aqueous humor was completely replaced by Biolon (sodium hyaluronate 1.0%) in Group A, by a combination of Viscoat (sodium chondroitin sulfate 4.0%–sodium hyaluronate 3.0%) and Provisc (sodium chondroitin sulfate 1.0%) using the soft-shell technique in Group B, and by a combination of Visiol (sodium hyaluronate 2.0%–mannitol 0.5%) and Biolon using the soft-shell technique in Group C. The eyes were exposed to alternating 10 seconds of phacoemulsification and a 10-second pause until a total exposure time of 2.5 minutes elapsed. Endothelial cell counts were repeated 3 days after surgery. Results The study used 18 rabbit eyes, 6 in each group. Group A had the highest endothelial cell loss (13%) followed by Group B (7%), and Group C (4%). The difference in cell loss between Group C and Group A was statistically significant ( P = .037). Conclusion The study showed the efficiency and advantages of the soft-shell technique using the combination of Visiol and Biolon over Biolon alone. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned. |
| Databáze: | OpenAIRE |
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