The release of a leukotriene D4-like substance following myocardial infraction in rabbits
| Autor: | Samuel Barst, Kevin Mullane |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Leukotriene D4 Guinea Pigs Myocardial Infarction 4 5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine Ileum Tripeptide In Vitro Techniques chemistry.chemical_compound Lipoxygenase Internal medicine medicine Animals Myocardial infarction Pharmacology Leukotriene Lagomorpha biology Heart respiratory system medicine.disease biology.organism_classification Rats N-Formylmethionine Leucyl-Phenylalanine Perfusion Endocrinology medicine.anatomical_structure chemistry Enzyme inhibitor biology.protein Pyrazoles Biological Assay SRS-A Rabbits Muscle Contraction |
| Zdroj: | European Journal of Pharmacology. 114:383-387 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(85)90384-x |
| Popis: | Myocardial infarction was induced in rabbits and 24-48 h later the hearts were removed and perfused in vitro with the coronary effluent superfusing a guinea-pig ileum. The formyl tripeptide (FMLP: 10-100 ng) induced the dose-related release of a substance which contracted the ileum, an effect mimicked by exogenous LTD4 (2-200 ng), blocked by FPL 55712 (2 micrograms/ml) and inhibited with BW755C (2 micrograms/ml) but not indomethacin (1 micrograms/ml). The delayed release of this LTD4-like material may suggest a role in the complications accompanying myocardial infarction. |
| Databáze: | OpenAIRE |
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