Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study
Autor: | Julia, Raschenberger, Barbara, Kollerits, Stephanie, Titze, Anna, Köttgen, Barbara, Bärthlein, Arif B, Ekici, Lukas, Forer, Sebastian, Schönherr, Hansi, Weissensteiner, Margot, Haun, Christoph, Wanner, Kai-Uwe, Eckardt, Florian, Kronenberg, Jennifer, Nadal |
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Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty Population Polymerase Chain Reaction Coronary artery disease Risk Factors Germany Internal medicine Diabetes mellitus Odds Ratio medicine Humans Prospective Studies Myocardial infarction education Prospective cohort study Aged education.field_of_study business.industry Odds ratio Middle Aged Telomere medicine.disease Aortic Aneurysm Surgery Cardiovascular Diseases Cohort Kidney Failure Chronic Female Cardiology and Cardiovascular Medicine business Glomerular Filtration Rate Kidney disease |
Zdroj: | Atherosclerosis. 242:529-534 |
ISSN: | 0021-9150 |
Popis: | Background Chronic kidney disease (CKD) affects 10–15% of the general population and affected individuals are at an increased risk for cardiovascular disease (CVD). Since telomere length is considered to be involved in biological aging, we tested whether relative telomere length (RTL) might be a marker for these two diseases. Methods The German Chronic Kidney Disease (GCKD) study is an ongoing prospective cohort study including patients with CKD of moderate severity. RTL was measured by qPCR in 4955 out of 5217 GCKD patients at baseline. Results RTL was distributed in the cohort with a mean ± SD of 0.95 ± 0.19. CVD was present in 1266 patients. Each decrease of RTL by 0.1 unit was associated with a higher probability for prevalent CVD: OR = 1.06, 95% CI 1.02–1.11, p = 0.007 (adjusted for age, sex, eGFR, BMI, ln-CRP, smoking, hypertension, diabetes, and lipids). Similar findings were observed for history of specific CVD entities, such as coronary artery disease (OR = 1.05, p = 0.025), myocardial infarction (OR = 1.08, p = 0.013) and percutaneous transluminal coronary angioplasty (OR = 1.06, p = 0.032). The strongest associations were found for interventions at the carotid arteries (OR = 1.25, p = 0.001) as well as aortic aneurysms (OR = 1.22, p = 0.001). Conclusions In the presence of CKD there is a significant association between shorter RTL and CVD manifestations. RTL appears to be a marker reflecting changes in homeostasis associated with CKD that may contribute to the excess CVD risk. |
Databáze: | OpenAIRE |
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