Computerized Tomography (CT) Updates and Challenges in Diagnosis of Bone Metastases During Prostate Cancer
| Autor: | Zhenhe Liu, Bin Yang, Jinguo Zhang, Guanzhong Zhai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Bone Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Major complication Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Bone metastasis Cancer Prostatic Neoplasms Middle Aged medicine.disease Review article Positron emission tomography 030220 oncology & carcinogenesis Radiology Tomography business Tomography X-Ray Computed Emission computed tomography |
| Zdroj: | Current medical imaging. 16(5) |
| ISSN: | 1573-4056 |
| Popis: | Prostate cancer is one of the most common cancers in men. This cancer is often associated with indolent tumors with little or no lethal potential. Some of the patients with aggressive prostate cancer have increased morbidity and early deaths. A major complication in advanced prostate cancer is bone metastasis that mainly results in pain, pathological fractures, and compression of spinal nerves. These complications in turn cause severe pain radiating to the extremities and possibly sensory as well as motor disturbances. Further, in patients with a high risk of metastases, treatment is limited to palliative therapies. Therefore, accurate methods for the detection of bone metastases are essential. Technical advances such as single-photon emission computed tomography/ computed tomography (SPECT/CT) have emerged after the introduction of bone scans. These advanced methods allow tomographic image acquisition and help in attenuation correction with anatomical co-localization. The use of positron emission tomography/CT (PET/CT) scanners is also on the rise. These PET scanners are mainly utilized with 18F-sodium-fluoride (NaF), in order to visualize the skeleton and possible changes. Moreover, NaF PET/CT is associated with higher tracer uptake, increased target-to-background ratio and has a higher spatial resolution. However, these newer technologies have not been adopted in clinical guidelines due to lack of definite evidence in support of their use in bone metastases cases. The present review article is focused on current perspectives and challenges of computerized tomography (CT) applications in cases of bone metastases during prostate cancer. |
| Databáze: | OpenAIRE |
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