Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure
| Autor: | Nghia T. Vo, Diogo M. Geraldes, Brian C Samuels, Julie Albon, Richard L. Abel, Andrew Feola, Baptiste Coudrillier, John J.E. Mulvihill, C. Ross Ethier |
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| Přispěvatelé: | Science and Technology Facilities Council, Georgia Research Alliance, National Aeronautics and Space Administration |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Lamina
Intraocular pressure genetic structures INTRACRANIAL-PRESSURE Swine Glaucoma Ophthalmology & Optometry NORMAL MONKEY EYES INTRAOCULAR-PRESSURE 0302 clinical medicine Nerve Fibers DISC EDEMA Cerebrospinal Fluid Pressure Medicine SPACE 11 Medical and Health Sciences Intracranial pressure PAPILLEDEMA Biomechanics Anatomy EXPERIMENTAL GLAUCOMA Biomechanical Phenomena HEAD CONNECTIVE-TISSUE cerebrospinal fluid pressure Optic nerve ACUTE IOP ELEVATION Female Anatomy and Pathology/Oncology Life Sciences & Biomedicine 3-D HISTOMORPHOMETRIC RECONSTRUCTIONS Optic Disk intracranial pressure ocular biomechanics Cribriform plate MICROGRAVITY 03 medical and health sciences Tonometry Ocular Animals Intraocular Pressure digital volume correlation ENVIRONMENT Science & Technology business.industry Optic Nerve phase-contrast micro-computed tomography X-Ray Microtomography 06 Biological Sciences medicine.disease BIOMECHANICS eye diseases Ophthalmology Disease Models Animal 030221 ophthalmology & optometry DURATION SPACE-FLIGHT Cerebrospinal fluid pressure sense organs business 030217 neurology & neurosurgery |
| Zdroj: | Investigative Ophthalmology & Visual Science |
| ISSN: | 1552-5783 0146-0404 |
| Popis: | Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased.\ud\udMethods: The posterior eye and RLNT of porcine eyes (n = 3) were imaged using synchrotron radiation phase-contrast micro-computed tomography (PC μCT) at an intraocular pressure of 15 mm Hg and CSFps of 4, 10, 20, and 30 mm Hg. Scans of each tissue region were acquired at each CSFp step and analyzed using digital volume correlation to determine 3-dimensional tissue deformations.\ud\udResults: Elevating CSFp increased the strain in the lamina cribrosa and RLNT of all three specimens, with the largest strains occurring in the RLNT. Relative to the baseline CSFp of 4 mm Hg, at 30 mm Hg, the lamina cribrosa experienced a mean first and third principal strain of 4.4% and −3.5%, respectively. The corresponding values for the RLNT were 9.5% and −9.1%.\ud\udConclusions: CSFp has a significant impact on the strain distributions within the lamina cribrosa and, more prominently, within the RLNT. Elevations in CSFp were positively correlated with increasing deformations in each region and may play a role in ocular pathologies linked to changes in CSFp. |
| Databáze: | OpenAIRE |
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