Endoscopic ultrasound-guided fine needle aspiration cytology of solid liver lesions: a large single-center experience
| Autor: | John M. DeWitt, Dan Ciaccia, Julia K. Leblanc, Lee McHenry, Tom Imperiale, John Chappo, Melissa Chriswell, Harvey M. Cramer, Kathy McGreevy, Stuart Sherman |
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| Rok vydání: | 2003 |
| Předmět: |
Endoscopic ultrasound
Male medicine.medical_specialty Cytodiagnosis Single Center Sensitivity and Specificity Endosonography Cohort Studies Diagnosis Differential Fine needle aspiration cytology Biopsy medicine Confidence Intervals Humans Solid tumor Aged Probability Retrospective Studies Hepatology medicine.diagnostic_test business.industry Liver Diseases Biopsy Needle Liver Neoplasms Gastroenterology Middle Aged Immunohistochemistry Endoscopy Female Radiology business |
| Zdroj: | The American journal of gastroenterology. 98(9) |
| ISSN: | 0002-9270 |
| Popis: | The aim of this study was to report the sensitivity, cytological diagnoses, endoscopic ultrasound (EUS) features, complications, clinical impact, and long term follow-up of a large single-center experience with endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of benign and malignant solid liver lesions.A database of cytologic specimens from EUS-FNA was reviewed to identify all hepatic lesions aspirated between January, 1997, and July, 2002. Procedural indications, prior radiographic data, patient demographics, EUS examination results, complications, and follow-up data were obtained and recorded.EUS-FNA of 77 liver lesions in 77 patients was performed without complications. Of these 77 lesions, 45 (58%) were diagnostic for malignancy, 25 (33%) were benign, and seven (9%) were nondiagnostic. A total of 22 lesions were confirmed as negative for malignancy by follow-up (mean 762 days, range 512-1556 days) or intraoperative examination; however, seven lesions could not be classified as benign or malignant. Depending on the status of the seven unclassified lesions, sensitivity of EUS-FNA for the diagnosis of malignancy ranged from 82 to 94%. When compared with benign lesions, EUS features predictive of malignant hepatic masses were the presence of regular outer margins (60% vs 27%; p = 0.02) and the detection of two or more lesions (38% vs 9%; p = 0.03). Of the 42 patients with malignancy identified by EUS-FNA and other available imaging records, EUS detected the malignancy in 41% of patients with previously negative examinations. For the 45 subjects with cytology positive for malignancy, EUS-FNA changed management in 86% of subjects.EUS-FNA of the liver is a safe and sensitive procedure that can have a significant impact on patient management. Prospective studies comparing the accuracy and complication rate of EUS-FNA and percutaneous fine needle aspiration (P-FNA) for the diagnosis of liver tumors are needed. |
| Databáze: | OpenAIRE |
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