Supplementary figures and methods from Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

Autor: Bin Zhao, Xin-Hua Feng, Tingbo Liang, Sheng Ye, Yu-Sheng Cong, Li Li, Zongping Xia, Mei Tang, Qi Zhou, Chu Zhu, Haitao Zhang, Huan Yan, Xiaocan Guo, Hongxia Zhao, Lingyi Xu, Xiaoming Dai, Xiaolei Cao, Xinyan Ji, Yuan Si
Rok vydání: 2023
DOI: 10.1158/0008-5472.22415325.v1
Popis: This supplementary data file contains the detailed methods section and six figures. Figure S1 shows cell-matrix adhesion induces tyrosine phosphorylation of Lats1, and is related to Figure 1. Figure S2 shows Src phosphorylates Lats1/2, and is related to Figure 2. Figure S3 shows the effect of CSK on Lats1 tyrosine phosphorylation, and is related to Figure 3. Figure S4 shows the identification of Lats1 residues phosphorylated by Src, and is related to Figure 4. Figure S5 shows that Src activates YAP through inhibition of Lats1, and is related to Figure 5. Figure S6 provides essential controls to Figure 6.
Databáze: OpenAIRE