Acute Systemic Inflammation Increases Arterial Stiffness and Decreases Wave Reflections in Healthy Individuals
| Autor: | Carmen Vasiliadou, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, Marina Toutouza, Ioanna Dima, Charalambos Vlachopoulos, Christodoulos Stefanadis, Constadina Aggeli |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Salmonella Vaccines Aorta Thoracic Blood Pressure Inflammation Vasodilation Systemic inflammation Ventricular Function Left Reference Values Physiology (medical) Internal medicine medicine Humans Cardiac Output Pulse wave velocity business.industry Vascular disease Vaccination Stroke Volume medicine.disease Surgery Peripheral Echocardiography Arterial stiffness Cardiology Female Vascular Resistance Aortic stiffness medicine.symptom Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Circulation. 112:2193-2200 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.105.535435 |
| Popis: | Background— Aortic stiffness is a marker of cardiovascular disease and an independent predictor of cardiovascular risk. Although an association between inflammatory markers and increased arterial stiffness has been suggested, the causative relationship between inflammation and arterial stiffness has not been investigated. Methods and Results— One hundred healthy individuals were studied according to a randomized, double-blind, sham procedure–controlled design. Each substudy consisted of 2 treatment arms, 1 with Salmonella typhi vaccination and 1 with sham vaccination. Vaccination produced a significant ( P P P P P P =NS for both). Conclusions— This is the first study to show through a cause-and-effect relationship that acute systemic inflammation leads to deterioration of large-artery stiffness and to a decrease in wave reflections. These findings have important implications, given the importance of aortic stiffness for cardiovascular function and risk and the potential of therapeutic interventions with antiinflammatory properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|