Cardio-renal safety of non-steroidal anti-inflammatory drugs
| Autor: | Zaher A. Radi, K Nasir Khan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
010501 environmental sciences
Pharmacology Toxicology Kidney 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences 0302 clinical medicine Medicine Animals Humans 0105 earth and related environmental sciences biology business.industry Myocardium Anti-Inflammatory Agents Non-Steroidal Heart digestive system diseases Pathophysiology medicine.anatomical_structure Non steroidal anti inflammatory Cyclooxygenase 2 biology.protein Cyclooxygenase 1 Cyclooxygenase business |
| Zdroj: | The Journal of toxicological sciences. 44(6) |
| ISSN: | 1880-3989 |
| Popis: | Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used therapeutic class in clinical medicine. These are sub-divided based on their selectivity for inhibition of cyclooxygenase (COX) isoforms (COX-1 and COX-2) into: (1) non-selective (ns-NSAIDs), and (2) selective NSAIDs (s-NSAIDs) with preferential inhibition of COX-2 isozyme. The safety and pathophysiology of NSAIDs on the renal and cardiovascular systems have continued to evolve over the years following short- and long-term treatment in both preclinical models and humans. This review summarizes major learnings on cardiac and renal complications associated with pharmaceutical inhibition of COX-1 and COX-2 with focus on preclinical to clinical translatability of cardio-renal data. |
| Databáze: | OpenAIRE |
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