Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract
| Autor: | Ana Lucia Rosa Nascimento, Mario José dos Santos Pereira, G. Diré, Jorge José de Carvalho, Luiz Querino de Araújo Caldas, S.R.F. Moreno, Mario Bernardo-Filho, Adriano Arnobio, Emely Kazan Rocha |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Multidisciplinary
biology Chemistry Ginkgo biloba lcsh:Biotechnology radiobiocomplex Pharmacology biology.organism_classification sodium pertechnetate Sodium pertechnetate Bioavailability chemistry.chemical_compound Ginkgo biloba extract medicine.anatomical_structure Morphometric analysis Pharmacokinetics lcsh:TP248.13-248.65 Duodenum medicine bioavailability morphometry |
| Zdroj: | Brazilian Archives of Biology and Technology, Vol 48, Iss spe2, Pp 73-78 (2005) Brazilian Archives of Biology and Technology v.48 n.spe2 2005 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Volume: 48, Issue: spe2, Pages: 73-78, Published: OCT 2005 |
| ISSN: | 1678-4324 1516-8913 |
| Popis: | Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (PSubstâncias podem interferir na biodisponibilidade de radiobiocomplexos, como os radiofármacos. O extrato de Ginkgo Biloba (EGb) apresenta efeitos. Avaliou-se a influência de um EGb na biodisponibilidade do pertecnetato de sódio (99mTcO-4Na) e na morfometria de órgãos de ratos que foram tratados com EGb. 99mTcO-4Na foi injetado, os animais sacrificados e a radioatividade nos órgãos contada. Os resultados mostraram que o EGb alterou a biodisponibilidade do 99mTcO-4Na em rins, fígado e duodeno e alterações morfométricas significativas (p |
| Databáze: | OpenAIRE |
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