Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia
| Autor: | Suzanne S. Summer, Amanda L. Stein, Marcelle D. Shidler, Robert Krikorian, Jane E. McDonald, Wilhelmina Kalt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Metabolite Urinary system Flavonoid Medicine (miscellaneous) Urine Anthocyanins 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology medicine Dementia TX341-641 Food science Effects of sleep deprivation on cognitive performance Cognitive impairment chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics business.industry Nutrition. Foods and food supply fungi food and beverages Mild cognitive impairment 04 agricultural and veterinary sciences medicine.disease Blueberries 040401 food science Phase 2 metabolites chemistry business Neurocognitive Food Science |
| Zdroj: | Journal of Functional Foods, Vol 64, Iss, Pp 103667-(2020) |
| ISSN: | 1756-4646 |
| Popis: | We performed a randomized, double blind, placebo-controlled trial with blueberry supplementation in older adults with mild cognitive impairment. We measured cognitive performance and parent (unmodified food form) anthocyanins and a suite of flavonoid-based phase 2 metabolites arising from anthocyanins in urine. The blueberry-treated group exhibited improved semantic access (p = 0.01) and visual-spatial memory (p = 0.05), and there was a trend for enhanced speed of processing (p = 0.08). There was no group difference in urinary excretion of total anthocyanins (parent plus metabolite forms) due to an abundance of phase 2 metabolites in both groups. However, parent anthocyanins (less than 0.1% of total) were 100 times greater in the blueberry group and were correlated with neurocognitive benefit. Ongoing blueberry intake introduced in advance of dementia improved cognitive performance, which was correlated specifically with the recent intake of blueberry and an abundance of parent anthocyanins. |
| Databáze: | OpenAIRE |
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