A 4-Month Whole-Systems Ayurvedic Medicine Nutrition and Lifestyle Intervention Is Feasible and Acceptable for Breast Cancer Survivors: Results of a Single-Arm Pilot Clinical Trial
| Autor: | Christine Miaskowski, Hope S. Rugo, Shelley R. Adler, Wendy Hartogensis, Ted J. Kaptchuk, Cairn Wu, Anand Dhruva, Sangeeta Agarawal, Rucha Kelkar, Ellen Garris, Frederick Hecht, Amisha Vadodaria |
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| Rok vydání: | 2020 |
| Předmět: |
integrative medicine
medicine.medical_specialty complementary therapies Ayurvedic medicine Ayurvedic Medicine Whole systems 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Quality of life Lifestyle intervention Medicine 030212 general & internal medicine Medical nutrition therapy lcsh:R5-920 business.industry lcsh:Public aspects of medicine lcsh:RA1-1270 General Medicine medicine.disease humanities Clinical trial cancer survivorship yoga 030220 oncology & carcinogenesis Physical therapy Original Article Integrative medicine business lcsh:Medicine (General) nutritional therapy |
| Zdroj: | Global Advances in Health and Medicine Global Advances in Health and Medicine, Vol 9 (2020) |
| ISSN: | 2164-957X |
| Popis: | Purpose Ongoing symptoms and impairments in quality of life (QOL) among breast cancer survivors remain a significant problem. We tested the feasibility and acceptability of a manualized Ayurvedic nutrition and lifestyle intervention for breast cancer survivors. Methods Eligible participants had Stage I–III breast cancer, underwent treatment within the past year that included chemotherapy, and were without active disease. The 4-month individualized Ayurvedic intervention included counseling on nutrition, lifestyle, yoga, and marma (like acupressure) during 8 one-on-one visits with an Ayurvedic practitioner. Feasibility and acceptability were the primary outcomes. QOL (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire [EORTC QLQ C30]) and symptoms—sleep disturbance (General Sleep Disturbance Scale [GSDS]), fatigue (Lee Fatigue Scale [LFS]), depressive symptoms (Center for Epidemiological Studies—Depression Scale [CES-D]), anxiety (Spielberger State-Trait Anxiety Inventory [STAI-S, STAI-T]), and stress (Perceived Stress Scale [PSS])—were measured prior to, at midpoint, and at the end of the 4-month intervention. Effect sizes (Cohen’s d) were calculated along with paired t tests comparing baseline to end of month 4 time points. Mixed effects models were used for repeated measures analyses. Results Participants ( n = 32) had a mean age of 48 years ( SD = 10). Retention at the end of the intervention was 84%. Among those who completed the intervention ( n = 27), adherence was high (99.5% of visits with practitioners attended). Large improvements were seen in QLQ-C30 emotional functioning ( d = 0.84, P Conclusion This 4-month Ayurvedic whole-systems multimodal nutrition and lifestyle intervention was feasible and acceptable for breast cancer survivors. Promise of clinical benefit was seen in terms of improvements in symptoms and QOL that warrants further investigation. |
| Databáze: | OpenAIRE |
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