Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition
| Autor: | Luca Pilloni, Franco Rongioletti, Caterina Matucci-Cerinic, Caterina Ferreli, Laura Atzori |
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| Přispěvatelé: | Atzori, Laura, Ferreli, Caterina, Matucci-Cerinic, Caterina, Pilloni, Luca, Rongioletti, Franco |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pathology limited cutaneous systemic sclerosis Connective tissue Case Report Dermatology Plasma cell Asymptomatic Dyscrasia 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine primary localized cutaneous nodular amyloidosis medicine business.industry medicine.disease Connective tissue disease Primary localized cutaneous nodular amyloidosis Amyloid deposition medicine.anatomical_structure connective tissue disease 030220 oncology & carcinogenesis RL1-803 Histopathology medicine.symptom dermoscopy business |
| Zdroj: | Dermatopathology, Vol 8, Iss 28, Pp 229-235 (2021) Dermatopathology |
| Popis: | Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition due to the plasma cell proliferation and skin deposition of immunoglobulin light chains, without systemic amyloidosis or hematological dyscrasias. The association with autoimmune connective tissue diseases has been reported, especially with Sjogren’s syndrome, and in a few cases with systemic sclerosis. Herein, we describe three cases of PLCNA occurring in women with a diagnosis of limited cutaneous systemic sclerosis and review the literature on the topic to highlight a stereotypical presentation. Moreover, we support the usefulness of dermoscopy, characterized by a yellow–orange waxy pattern surrounded by telangiectasias, for a rapid and non-invasive diagnostic assessment. Thus, when asymptomatic nodules occur on lower limbs of women affected with limited systemic sclerosis, and dermoscopy identifies yellow–orange blotches, a diagnosis of PLCNA can be considered and further confirmed by histopathology. Monitoring for systemic amyloidosis development is advisable, although the risk of progression is considered very low. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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