Postoperative mortality after surgery for inflammatory bowel disease in the era of biological agents: A population-based study in Southern Europe
| Autor: | Emili Vela, Montserrat Cleries, David Parés, Fiorella Cañete, José Troya, M Calafat, Alex Guarga, Montserrat Guasch, Míriam Mañosa, Eugeni Domènech |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population Comorbidity Disease Logistic regression Inflammatory bowel disease 03 medical and health sciences Postoperative Complications 0302 clinical medicine Crohn Disease Humans Medicine Mortality education Digestive System Surgical Procedures Colectomy education.field_of_study Hepatology business.industry Gastroenterology Odds ratio medicine.disease Ulcerative colitis Surgery Crohn's disease Spain 030220 oncology & carcinogenesis Colitis Ulcerative 030211 gastroenterology & hepatology business |
| Zdroj: | Digestive and Liver Disease r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname |
| ISSN: | 1590-8658 |
| Popis: | Background: : Despite the efficacy of biological agents, surgery is still required for a large percentage of patients with inflammatory bowel disease (IBD). Aims: To assess the postoperative mortality rates and associated risk factors in IBD patients in a population-based setting in the era of biological agents. Methods: This is a population-based longitudinal study including all patients diagnosed with IBD in Catalonia who underwent intestinal resection or colectomy between 2007 and 2016, identified from the Catalan Health Surveillance System database. Logistic regression was used to calculate the adjusted odds ratio for postoperative in-hospital and 30-day mortality. Data for Crohn's disease (CD) and ulcerative colitis (UC) were analysed separately. Results: A total of 1,660 interventions for CD (69%) and 738 for UC (31%) were performed at 55 centres. In-hospital and 30-day postoperative mortality rates were 2.1% and 2.5% for CD, and 5.4% and 6.4% for UC, respectively. In the multivariate logistic regression analysis, comorbidity was associated with in-hospital and 30-day postoperative mortality in CD and UC, whereas age was only associated with mortality in CD and a non-laparoscopic surgical approach with UC. Conclusions: In the era of biologicals, the postoperative mortality rate for IBD depends mostly on comorbidities and age. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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