Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4
| Autor: | Mei Zhang, Hui Ming Ge, Jing Shi, Ren-Xiang Tan, Bo Zhang, Xin Zhao Deng, Rui Hua Jiao, Yong Sheng Xiao, Zhi-Kai Guo, Wei Li |
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| Rok vydání: | 2017 |
| Předmět: |
Models
Molecular medicine.drug_class Morpholines Antibiotics Molecular Conformation Crystallographic data Grasshoppers Microbial Sensitivity Tests 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Microbiology Actinobacteria Amycolatopsis sp chemistry.chemical_compound Morpholine medicine Animals Physical and Theoretical Chemistry biology 010405 organic chemistry Chemistry Organic Chemistry Rifamycin biology.organism_classification 0104 chemical sciences Anti-Bacterial Agents Staphylococcus aureus Locust |
| Zdroj: | Organicbiomolecular chemistry. 15(18) |
| ISSN: | 1477-0539 |
| Popis: | Cultivation of locust associated rare actinobacteria, Amycolatopsis sp. HCa4, has provided five unusual macrolactams rifamorpholines A-E. Their structures were determined by interpretation of spectroscopic and crystallographic data. Rifamorpholines A-E possess an unprecedented 5/6/6/6 ring chromophore, representing a new subclass of rifamycin antibiotics. The biosynthetic pathway for compounds 1-5 involves a key 1,6-cyclization for the formation of the morpholine ring. Compounds 2 and 4 showed potent activities against methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 4.0 and 8.0 μM, respectively. |
| Databáze: | OpenAIRE |
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