Effects of prenatal chlorocholine chloride exposure on pubertal development and reproduction of male offspring in rats
| Autor: | Chenping Kang, Qianqian Xiao, Hong Hu, Bayindala Xiagedeer, Jianjun Jiang, Qinghe Meng, Xiaohong Hou, Weidong Hao |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Chlormequat Offspring media_common.quotation_subject Preputial gland Biology Toxicology Plant Growth Regulators Pregnancy Internal medicine medicine Animals Sexual Maturation Sperm motility Infertility Male media_common General Medicine medicine.disease Hypothalamic–pituitary–thyroid axis Rats Semen Analysis Endocrinology Prenatal Exposure Delayed Effects Sperm Motility Female Reproduction Spermatogenesis Hormone |
| Zdroj: | Toxicology letters. 351 |
| ISSN: | 1879-3169 |
| Popis: | Chlorocholine chloride (CCC) promote plant growth as a regulator. Emerging evidence by our group showed that CCC might restrain the puberty onset and impair the reproductive functions in male rats through HPT axis. In this study, we further investigated the effects of prenatal CCC exposure on pubertal development, reproduction of male offspring in rats and explored the underlying mechanisms. The results showed that CCC of 137.5 and 200 mg/kg bw/day delayed the age of preputial separation (PPS), decreased the sperm motility of male offspring. PP1γ2 which is an essential protein in spermatogenesis reduced in 137.5 and 200 mg/kg bw/day groups. Crucial hormones involved in hypothalamic-puititary-testicular (HPT) axis decreased at postnatal day (PND) 30. It was indicated that CCC exposure in pregnancy might disturb the pubertal development, reproductive functions of male offspring through HPT axis and disturb the sperm motility through PP1γ2. |
| Databáze: | OpenAIRE |
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