A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER
| Autor: | Alain Tagnon, F Fortin, Dany Brohée, C Vanschaardenburg, P. Mommen, M.C. Berchier, Roger Sergysels, Jean-Sébastien Lecomte, U. Küstner, Richard, Jacques Thiriaux, Jean Klastersky, Jj Lafitte, D Diana, Gérard Bureau, Marianne Paesmans, P Recloux, Jp Sculier |
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| Rok vydání: | 1995 |
| Předmět: |
Oncology
Cisplatin Cancer Research medicine.medical_specialty Chemotherapy business.industry medicine.medical_treatment Cancer Phases of clinical research Salvage therapy Combination chemotherapy medicine.disease Carboplatin Nephrotoxicity chemistry.chemical_compound chemistry Internal medicine medicine business medicine.drug |
| Zdroj: | International Journal of Oncology. |
| ISSN: | 1791-2423 1019-6439 |
| DOI: | 10.3892/ijo.6.2.425 |
| Popis: | A phase II trial was conducted to determine the effectiveness of weekly administration of cisplatin (25 mg/m(2) on day 1) and carboplatin (100 mg/m(2) on day 1) as salvage chemotherapy for patients with small cell lung cancer after first-line chemotherapy without platinum derivatives. Of 40 eligible patients, 38 were evaluable for response. Interval between last course of first-line chemotherapy and first course of salvage therapy was less than 3 months in 34 and greater in 4. Five partial responses (13%; confidence interval at 95%:0.01-0.25) were documented (including 4 in patients with a treatment-free interval |
| Databáze: | OpenAIRE |
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