Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities
| Autor: | Sian Pan, Tian Zhao, Xiaopeng Zhu, Guohong Hu, Xueping Yao, Libin Liao, Shiwen Wang, Huiting Weng, Yanshan Ge |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Cell growth Lactoferrin DNA damage Cell Anti-Inflammatory Agents Antineoplastic Agents Apoptosis Cell cycle Biology Pharmacology Anti-Bacterial Agents Immunomodulating Agents Immune system medicine.anatomical_structure Adjuvants Immunologic Oncology Neoplasms Drug delivery medicine biology.protein Nanotechnology Nanocarriers |
| Zdroj: | International Journal of Oncology. 59 |
| ISSN: | 1791-2423 1019-6439 |
| Popis: | Lactoferrin (Lf) is secreted by ectodermal tissue and has a structure similar to that of transferrin. Although Lf seems to be multifunctional, its main function is related to the natural defense system of mammals. The present review aims to highlight the major actions of Lf, including the regulation of cell growth, the inhibition of toxic compound formation, the removal of harmful free radicals and its important role in immune response regulation. Moreover, Lf has antibacterial, antiviral, antioxidant, anticancer and anti‑inflammatory activities. In addition, the use of Lf for functionalization of drug nanocarriers, with emphasis on tumor‑targeted drug delivery, is illustrated. Such effects serve as an important theoretical basis for its future development and application. In neurodegenerative diseases and the brains of elderly people, Lf expression is markedly upregulated. Lf may exert an anti‑inflammatory effect by inhibiting the formation of hydroxyl free radicals. Through its antioxidant properties, Lf can prevent DNA damage, thereby preventing tumor formation in the central nervous system. In addition, Lf specifically activates the p53 tumor suppressor gene. |
| Databáze: | OpenAIRE |
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