EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study
| Autor: | Jean Paul Ortonne, Gunilla Huledal, Clélia Debure, Carle Paul, Bernard Guillot, Catherine Lok, Pierre Amblard, Brigitte Faivre, Bernard Kalis, Didier Bessis |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Lidocaine medicine.drug_class medicine.medical_treatment Pain Dermatology Administration Cutaneous Topical anesthetic Prilocaine Varicose Ulcer Ointments Double-Blind Method medicine Humans Local anesthesia Anesthetics Local Lidocaine Prilocaine Drug Combination Aged Wound Healing Debridement Local anesthetic business.industry Surgery Treatment Outcome Anesthesia Skin grafting Female business medicine.drug |
| Zdroj: | Journal of the American Academy of Dermatology. 40:208-213 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/s0190-9622(99)70190-8 |
| Popis: | Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain. Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses. Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements). Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15; P = .019) and decreased pain by 50% ( P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation. Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect