Effects of prostaglandin-E1on ST segment elevation and regional myocardial blood flow during experimental myocardial ischaemia in dogs
| Autor: | Richard C. Talbot, Michael F. Oliver, Ole D. Mjøs, Alex Ungar, Rudolph A. Riemersma |
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| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Coronary Disease Fatty Acids Nonesterified Anterior Descending Coronary Artery Biochemistry Electrocardiography chemistry.chemical_compound Dogs Coronary Circulation Isoprenaline Internal medicine Occlusion medicine Animals ST segment Prostaglandin E1 business.industry Myocardium Prostaglandins E Hemodynamics Isoproterenol General Medicine Blood flow Blood pressure chemistry Anesthesia Catecholamine Cardiology lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | European Journal of Clinical Investigation. 7:515-521 |
| ISSN: | 1365-2362 0014-2972 |
| Popis: | The effects of prostaglandin E1 (PGE1) on myocardial ischaemia (as measured by epicardial ST segment changes), myocardial flow and substrate exchange has been studied in dogs. Myocardial ischaemia was induced by intermittent external clipping of a branch of the left anterior descending coronary artery. During occlusion with a continuous intravenous infusion of isoprenaline, elevated epicardial ST segments (∑ST), were raised to 46 ± 6 mV (mean ± SEM). Pretreatment with PGE1 reduced ∑ST to 34 ± 6 mV (P |
| Databáze: | OpenAIRE |
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