14,15-Epoxyeicosatrienoic Acid Represents a Transferable Endothelium-Dependent Relaxing Factor in Bovine Coronary Arteries
| Autor: | Dendi S. Reddy, John R. Falck, Kathryn M. Gauthier, Erik M. Edwards, William B. Campbell |
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| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Endothelium Bradykinin Vasodilation In Vitro Techniques Epoxyeicosatrienoic acid Muscle Smooth Vascular chemistry.chemical_compound 8 11 14-Eicosatrienoic Acid Internal medicine Internal Medicine medicine Animals Endothelium-Dependent Relaxing Factors biology Chemistry Hyperpolarization (biology) Coronary Vessels Nitric oxide synthase Coronary arteries medicine.anatomical_structure Endocrinology cardiovascular system biology.protein Cardiology Biological Assay Cattle Endothelium Vascular Artery |
| Zdroj: | Hypertension. 45:666-671 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000153462.06604.5d |
| Popis: | Bradykinin causes arterial relaxation and hyperpolarization, which is mediated by a transferable endothelium-derived hyperpolarizing factor (EDHF). In coronary arteries, epoxyeicosatrienoic acids (EETs) are involved in the EDHF response. However, the role of EETs as transferable mediators of EDHF-dependent relaxation remains poorly defined. Two small bovine coronary arteries were cannulated and perfused in tandem in the presence of the nitric oxide synthase inhibitor, nitro- l -arginine (30 μmol/L), and the cyclooxygenase inhibitor, indomethacin (10 μmol/L). Luminal perfusate from donor arteries with intact endothelium perfused endothelium-denuded detector arteries. Detector arteries were constricted with U46619 and diameters were monitored. Bradykinin (10 nmol/L) added to detector arteries did not induce dilation (5±2%), whereas bradykinin addition to donor arteries dilated detector arteries by 26.5±7% ( P |
| Databáze: | OpenAIRE |
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