Hallucinations and Delusions Signal Alzheimer’s Associated Cognitive Dysfunction More Strongly Compared to Other Neuropsychiatric Symptoms
| Autor: | Joshua Fuller, Alzheimer’s Disease Neuroimaging Initiative, Deborah A. Lowe, Steve Balsis, Tabina K. Choudhury |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Databases Factual Hallucinations Social Psychology education Neurocognitive Disorders Neuroimaging Disease The Journal of Gerontology: Psychological Sciences Delusions 03 medical and health sciences 0302 clinical medicine Alzheimer Disease parasitic diseases mental disorders medicine Humans Dementia Cognitive Dysfunction Apathy Correlation of Data Depression (differential diagnoses) Aged Psychiatric Status Rating Scales 030214 geriatrics business.industry technology industry and agriculture Brain Cognition Organ Size Mental Status and Dementia Tests medicine.disease Clinical Psychology nervous system Anxiety Female Geriatrics and Gerontology medicine.symptom business Gerontology Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | J Gerontol B Psychol Sci Soc Sci |
| ISSN: | 1758-5368 1079-5014 |
| DOI: | 10.1093/geronb/gbz032 |
| Popis: | ObjectivesNeuropsychiatric symptoms (NPS) are common among individuals with dementia of the Alzheimer’s type (DAT). We sought to characterize which NPS more purely relate to cognitive dysfunction in DAT, relative to other NPS.MethodDemographic, neurocognitive, neuroimaging, and NPS data were mined from the Alzheimer’s Disease Neuroimaging Initiative database (n = 906). Using factor analysis, we analyzed the degree to which individual NPS were associated with DAT-associated cognitive dysfunction. We also employed item response theory to graphically depict the ability of individual NPS to index DAT-associated cognitive dysfunction across a continuum ranging from cognitively normal to mild DAT.ResultsPsychotic symptoms (hallucinations and delusions) were more strongly related to the continuum of DAT-associated cognitive dysfunction than other NPS, with the strength of the relationship peaking at high levels of disease severity. Psychotic symptoms also negatively correlated with brain volume and did not relate to the presence of vision problems. Aberrant motor behavior and apathy had relatively smaller associations with DAT-associated cognitive dysfunction, while other NPS showed minimal associations.DiscussionPsychotic symptoms most strongly indexed DAT-associated cognitive dysfunction, whereas other NPS, such as depression and anxiety, were not as precisely related to the DAT-associated cognitive dysfunction. |
| Databáze: | OpenAIRE |
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