Bone mineral density in adults with Down syndrome
| Autor: | Davide L. Vetrano, D. Mascia, R. Liperoti, Graziano Onder, Vincenzo Brandi, Emanuele Rocco Villani, Domenico Fusco, E Manes Gravina, E. Meloni, Angelo Carfì, Roberto Bernabei, Silvia Giovannini |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Aging Pediatrics medicine.medical_specialty Bone density National Health and Nutrition Examination Survey Endocrinology Diabetes and Metabolism Osteoporosis Population 030209 endocrinology & metabolism Short stature Cohort Studies Young Adult 03 medical and health sciences Absorptiometry Photon Sex Factors 0302 clinical medicine Bone Density medicine Humans education Aged Femoral neck Bone mineral education.field_of_study Lumbar Vertebrae Anthropometry Femur Neck business.industry Bone fracture Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Female Down Syndrome medicine.symptom business |
| Zdroj: | Osteoporosis International. 28:2929-2934 |
| ISSN: | 1433-2965 0937-941X |
| DOI: | 10.1007/s00198-017-4133-x |
| Popis: | This study analyzed data of bone mineral density (BMD) from a large cohort of adults with Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects than in the general population, exposing adults with DS to an increased risk of osteoporosis and bone fracture. Down syndrome (DS) in adulthood presents with a high prevalence of osteoporosis. However, in DS, bone mineral density (BMD) can be underestimated due to short stature. Furthermore, the rate of age-related decline in BMD and its association with gender in DS has been rarely evaluated or compared with the general population. The present study is aimed at assessing the variation of BMD with age and gender in a sample of adults with DS and to compare these data with those of the general population, after adjusting for anthropometric differences. Adults with DS, aged 18 or older, were assessed dual-energy-X-ray-absorptiometry (DXA) at the femoral neck and at the lumbar spine. They were compared with the general population enrolled in the National Health and Nutrition Examination Survey (NHANES) 2009–2010 dataset. Bone mineral apparent density (BMAD) was calculated for each individual. DXA was evaluated in 234 subjects with DS (mean age 36.93 ± 11.83 years, ranging from 20 to 69 years; 50.4% females). In the lumbar spine both mean BMD (DS 0.880 ± 0.141 vs. NHANES 1.062 ± 0.167, p |
| Databáze: | OpenAIRE |
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