Sex-specific hippocampus volume changes in obstructive sleep apnea

Autor: Mary A. Woo, Ronald M. Harper, Jennifer A. Ogren, Ammar S. Moiyadi, M. Albert Thomas, Ravi S. Aysola, Janani P. Prasad, Paul M. Macey, Rajesh Kumar, Frisca L. Yan-Go
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
AHI
apnea-hypopnea index
Hippocampus
Hippocampal formation
lcsh:RC346-429
0302 clinical medicine
Medicine
10. No inequality
obstructive sleep apnea
Sleep disorder
Sex Characteristics
Sleep Apnea
Obstructive
CA
Subiculum
Regular Article
Intermittent hypoxia
Organ Size
Middle Aged
Uncus
Magnetic Resonance Imaging
CA
cornu ammonis
Autonomic
Neurology
Brain size
Neurological
Cardiology
Biomedical Imaging
lcsh:R858-859.7
Female
cornu ammonis
Sleep Research
Adult
medicine.medical_specialty
Sleep Apnea
Cognitive Neuroscience
Polysomnography
Neuroimaging
lcsh:Computer applications to medicine. Medical informatics
OSA
03 medical and health sciences
Clinical Research
Internal medicine
Humans
Radiology
Nuclear Medicine and imaging
OSA
obstructive sleep apnea
lcsh:Neurology. Diseases of the nervous system
Inflammation
business.industry
Obstructive
Neurosciences
apnea-hypopnea index
medicine.disease
Brain Disorders
Obstructive sleep apnea
030104 developmental biology
nervous system
Oxidative stress
Neurology (clinical)
business
AHI
030217 neurology & neurosurgery
Zdroj: NeuroImage: Clinical, Vol 20, Iss, Pp 305-317 (2018)
Macey, PM; Prasad, JP; Ogren, JA; Moiyadi, AS; Aysola, RS; Kumar, R; et al.(2018). Sex-specific hippocampus volume changes in obstructive sleep apnea.. NeuroImage. Clinical, 20, 305-317. doi: 10.1016/j.nicl.2018.07.027. UCLA: Retrieved from: http://www.escholarship.org/uc/item/8vp859hj
NeuroImage : Clinical
ISSN: 2213-1582
Popis: Introduction Obstructive sleep apnea (OSA) patients show hippocampal-related autonomic and neurological symptoms, including impaired memory and depression, which differ by sex, and are mediated in distinct hippocampal subfields. Determining sites and extent of hippocampal sub-regional injury in OSA could reveal localized structural damage linked with OSA symptoms. Methods High-resolution T1-weighted images were collected from 66 newly-diagnosed, untreated OSA (mean age ± SD: 46.3 ± 8.8 years; mean AHI ± SD: 34.1 ± 21.5 events/h;50 male) and 59 healthy age-matched control (46.8 ± 9.0 years;38 male) participants. We added age-matched controls with T1-weighted scans from two datasets (IXI, OASIS-MRI), for 979 controls total (426 male/46.5 ± 9.9 years). We segmented the hippocampus and analyzed surface structure with “FSL FIRST” software, scaling volumes for brain size, and evaluated group differences with ANCOVA (covariates: total-intracranial-volume, sex; P
Highlights • The hippocampus in OSA shows areas of increased and decreased volume. • The injury is sex-specific, in subregions related to symptoms in females and males. • Injury may be inflammation (volume increases) or cell death (volume decreases).
Databáze: OpenAIRE
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