Cortical responses to tactile stimuli in preterm infants

Autor: Ninah Koolen, Susanna Leikos, Päivi Nevalainen, Sampsa Vanhatalo, Anton Tokariev
Přispěvatelé: Faculty of Medicine, Kliinisen neurofysiologian yksikkö, Department of Neurosciences, University of Helsinki, HUS Medical Imaging Center, HUS Children and Adolescents, Children's Hospital, HUSLAB, Department of Diagnostics and Therapeutics, BioMag Laboratory
Rok vydání: 2020
Předmět:
medicine.medical_specialty
brain monitoring
EARLY MOTOR-ACTIVITY
Stimulation
BRAIN-INJURY
Stimulus (physiology)
Audiology
Electroencephalography
TERM
Somatosensory system
3124 Neurology and psychiatry
SOMATOSENSORY-EVOKED-POTENTIALS
NEURODEVELOPMENTAL OUTCOMES
03 medical and health sciences
0302 clinical medicine
Subplate
somatosensory evoked potentials
Humans
Medicine
EEG
Cerebral Hemorrhage
030304 developmental biology
0303 health sciences
SPINDLE BURSTS
medicine.diagnostic_test
business.industry
General Neuroscience
Infant
Newborn
3112 Neurosciences
intraventricular haemorrhage
Infant
electroencephalogram
Neurophysiology
SUBPLATE NEURONS
medicine.disease
neonatal intensive care unit
Electric Stimulation
INTRAVENTRICULAR HEMORRHAGE
medicine.anatomical_structure
Intraventricular hemorrhage
Touch
Somatosensory evoked potential
VISUAL STIMULATION
NEONATAL EEG
business
Infant
Premature
030217 neurology & neurosurgery
Zdroj: European Journal of Neuroscience. 51:1059-1073
ISSN: 1460-9568
0953-816X
DOI: 10.1111/ejn.14613
Popis: The conventional assessment of preterm somatosensory functions using averaged cortical responses to electrical stimulation ignores the characteristic components of preterm somatosensory evoked responses (SERs). Our study aimed to systematically evaluate the occurrence and development of SERs after tactile stimulus in preterm infants. We analysed SERs performed during 45 electroencephalograms (EEGs) from 29 infants at the mean post-menstrual age of 30.7 weeks. Altogether 2,087 SERs were identified visually at single trial level from unfiltered signals capturing also their slowest components. We observed salient SERs with a high amplitude slow component at a high success rate after hand (95%) and foot (83%) stimuli. There was a clear developmental change in both the slow wave and the higher frequency components of the SERs. Infants with intraventricular haemorrhage (IVH; eleven infants) had initially normal SERs, but those with bilateral IVH later showed a developmental decrease in the ipsilateral SER occurrence after 30 weeks of post-menstrual age. Our study shows that tactile stimulus applied at bedside elicits salient SERs with a large slow component and an overriding fast oscillation, which are specific to the preterm period. Prior experimental research indicates that such SERs allow studying both subplate and cortical functions. Our present findings further suggest that they might offer a window to the emergence of neurodevelopmental sequalae after major structural brain lesions and, hence, an additional tool for both research and clinical neurophysiological evaluation of infants before term age.
Databáze: OpenAIRE
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