Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells
| Autor: | M.W. Ghilchik, M.J. Reed, Nick G. Coldham, S.R. Patel, James Vh |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Breast Neoplasms Biology Endocrinology Breast cancer Aromatase Internal medicine medicine Tumor Cells Cultured Humans Interleukin 6 Fibrocystic Breast Disease Dexamethasone Interleukin-6 Interleukin Radioimmunoassay medicine.disease Cytokine biology.protein Female Cell Division medicine.drug Interleukin-1 |
| Zdroj: | The Journal of endocrinology. 132(3) |
| ISSN: | 0022-0795 |
| Popis: | Gross cystic breast disease is a common benign disease which may be associated with an increased risk for breast cancer. Breast cyst fluid (BCF) contains many steroids, peptide growth factors and proteins. We have now identified interleukin-1 (IL-1) and IL-6 in BCF by specific radioimmunoassays. Concentrations of IL-1 were similar in BCF with low or high Na+/K+ ratios (ratio 3; 357 ± 72 pg/ml vs 308 ± 126 pg/ml). In contrast, IL-6 concentrations were significantly higher (P+/K+ ratio >3 (2.75 ± 2.34 ng/ml) compared with BCF with a low electrolyte ratio (0.21 ± 0.09 ng/ ml). BCF (10%, v/v) stimulated aromatase activity when added to dexamethasone stimulated breast tumour-derived fibroblasts and there was a significant correlation between the stimulation of aromatase activity and BCF Na+/K+ ratio (r = 0.95, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|