The management of hyperleukocytosis in an adult patient with acute lymphoblastic leukemia and ataxia-telangiectasia
| Autor: | Gulsah Akyol, Muzaffer Keklik, Mustafa Cetin, Musa Solmaz, Ali Ünal, Burhan Sami Kalin, Leylagül Kaynar, Serdar Sivgin, Cigdem Pala, Bulent Eser |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Leukocytosis Nausea Leucovorin Ataxia Telangiectasia Internal medicine White blood cell Antineoplastic Combined Chemotherapy Protocols medicine Asparaginase Humans Leukapheresis Telangiectasia Immunodeficiency Hematology business.industry Emergency department Precursor Cell Lymphoblastic Leukemia-Lymphoma Flow Cytometry Prognosis medicine.disease Surgery Methotrexate medicine.anatomical_structure Doxorubicin Vincristine Ataxia-telangiectasia Steroids medicine.symptom business |
| Popis: | Ataxia-telangiectasia (AT) is a hereditary disorder characterized by progressive neurological dysfunction, oculocutaneous telangiectasia, immunodeficiency, cancer susceptibility, and radiation sensitivity. Pediatric patients may develop acute lymphoblastic leukemia (ALL). However development of ALL in an adult patient with AT is a rare occurrence. Here we report such a patient who presented with hyperleukocytosis and were treated with leukapheresis. A 25 years old male patient, who were diagnosed with AT and mental retardation, was admitted to the emergency department due to fatigue, nausea and headache. On admission he had a moderate general condition and was fully cooperated. His white blood cell (WBC) count were 466 x 10(9)/l. Blastic cells were observed in peripheral blood smear. Flow cytometry (FC) of peripheral blood showed T-ALL Two sessions of large volume leukapheresis was performed. Symptoms due to hyperleukocytosis markedly improved after leukapheresis. Patients with AT should be closely monitored due to risk of malignancy. Leukapheresis may improve the prognosis of high risk ALL patients presenting with hyperleukocytosis. (C) 2013 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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