Pepsinogen and Serum IgG Detection Is a Valuable Diagnostic Method for Helicobacter pylori Infection in a Low-Prevalence Country: A Report from Sri Lanka
| Autor: | Takashi Matsumoto, Shamshul Ansari, Kartika Afrida Fauzia, Takeshi Matsuhisa, Dalla Doohan, M.D. Lamawansa, Junko Akada, Jeewantha Rathnayake, Bui Hoang Phuc, Vo Phuoc Tuan, Langgeng Agung Waskito, Azzaya Dashdorj, Evariste Tshibangu Kabamba, Tomohisa Uchida, Yoshio Yamaoka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) infectious disease Clinical Biochemistry prevalence Chronic gastritis Gastroenterology Group B Serology 03 medical and health sciences 0302 clinical medicine Atrophy R5-920 Pepsin Internal medicine Metaplasia medicine pepsinogen Sri Lanka biology business.industry Area under the curve Helicobacter pylori anti-Hp IgG biology.organism_classification medicine.disease gastroduodenal diseases 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Diagnostics, Vol 11, Iss 1364, p 1364 (2021) Diagnostics Volume 11 Issue 8 |
| ISSN: | 2075-4418 |
| Popis: | The use of serum anti-Helicobacter pylori IgG and pepsinogen (PG) detection as a diagnostic method was evaluated in Sri Lanka. Gastric biopsies were performed (353 patients), and the prevalence of H. pylori infection was 1.7% (culture) and 2.0% (histology). IgG serology testing showed an area under the curve (AUC) of 0.922 (cut-off, 2.95 U/mL specificity, 91.56% sensitivity, 88.89%). Histological evaluation showed mild atrophy (34.3%), moderate atrophy (1.7%), metaplasia (1.7%), chronic gastritis (6.2%), and normal tissue (56%). The PGI/PGII ratio was significantly higher in H. pylori-negative patients (p < 0.01). PGII and PGI/PGII levels were lower in patients with metaplasia than in those with normal mucosa (p = 0.049 and p < 0.001, respectively). The PGI/PGII ratio best discriminated metaplasia and moderate atrophy (AUC 0.88 and 0.76, respectively). PGI and PGII alone showed poor discriminative ability, especially in mild atrophy (0.55 and 0.53, respectively) and chronic gastritis (0.55 and 0.53, respectively). The best cut-off to discriminate metaplasia was 3.25 U/mL (95.19% specificity, 83.33% sensitivity). Anti-H. pylori IgG and PG assessment (ABC method) was performed (group B, 2.0% group A, 92.1%). The new cut-off more accurately identified patients with metaplasia requiring follow-up (group B, 5.4%). Assessment of anti-H. pylori IgG and PG is valuable in countries with a low prevalence of H. pylori infection. |
| Databáze: | OpenAIRE |
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