The association of lumican polymorphisms and high myopia in a Southern Chinese population
| Autor: | Qing-Shan Ji, Lian Liu, Guo-Cheng Yu, Gui-Fang Wang, Bing Qi, Jing-Xiang Zhong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Lumican
Population Single-nucleotide polymorphism 03 medical and health sciences single nucleotide polymorphisms 0302 clinical medicine lcsh:Ophthalmology Polymorphism (computer science) Genotype Medicine 030212 general & internal medicine Allele education high myopia Allele frequency Genetics education.field_of_study business.industry lumican Ophthalmology Exact test Basic Research lcsh:RE1-994 030211 gastroenterology & hepatology sclera business |
| Zdroj: | International Journal of Ophthalmology, Vol 10, Iss 10, Pp 1516-1520 (2017) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | AIM: To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population. METHODS: The study comprised of 95 high myopia patients with a spherical equivalent ≤−6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from −0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg disequilibrium. Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher’s exact test. RESULTS: We identified 3 SNPs of the LUM gene: LUM c.32 (rs577456426), LUM c.507 (rs17853500) and LUM c.849 (rs181915277). Among the three SNPs, the genotype and allele frequencies of rs17853500 showed a significant difference between patients and control subjects (P0.05). CONCLUSION: LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population. |
| Databáze: | OpenAIRE |
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