Acute kidney injury in critically ill patients with lung disease: kidney-lung crosstalk
| Autor: | Krasnalhia Lívia S. Abreu, Rafael S. A. Lima, Marcelo Alcântara Holanda, Elizabeth De Francesco Daher, Thalita Diógenes Muniz, Alexandre Braga Libório, Eanes Delgado Barros Pereira, Geraldo Bezerra da Silva Junior, Adller G.C. Barreto |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty medicine.medical_treatment Critical Illness Lung injury Critical Care and Intensive Care Medicine Positive-Pressure Respiration Renal Dialysis Internal medicine medicine Humans Prospective Studies Mortality Prospective cohort study Dialysis Aged Mechanical ventilation Kidney business.industry Mortality rate Incidence Acute kidney injury General Medicine Acute Kidney Injury Middle Aged medicine.disease Prognosis Respiration Artificial Surgery Oxygen Intensive Care Units medicine.anatomical_structure Risk factors Original Article Female Hemodialysis business Respiratory insufficiency Brazil |
| Zdroj: | Revista Brasileira de Terapia Intensiva |
| ISSN: | 1982-4335 0103-507X |
| Popis: | Objective: To examine the factors associated with acute kidney injury and outcome in patients with lung disease. Methods: A prospective study was conducted with 100 consecutive patients admitted to a respiratory intensive care unit in Fortaleza (CE), Brazil. The risk factors for acute kidney injury and mortality were investigated in a group of patients with lung diseases. Results: The mean age of the study population was 57 years, and 50% were male. The incidence of acute kidney injury was higher in patients with PaO2/ FiO 2 ≤200 mmHg (54% versus 23.7%; p=0.02). Death was observed in 40 cases and the rate of mortality of the acute kidney injury group was higher (62.8% versus 27.6%; p=0.01). The independent factor that was found to be associated with acute kidney injury was PaO 2 /FiO 2 ≤200 mmHg (p=0.01), and the independent risk factors for death were PEEP at admission (OR: 3.6; 95%CI: 1.3-9.6; p=0.009) and need for hemodialysis (OR: 7.9; 95%CI: 2.2-28.3; p=0.001). Conclusion: There was a higher mortality rate in the acute kidney injury group. Increased mortality was associated with mechanical ventilation, high PEEP, urea and need for dialysis. Further studies must be performed to better establish the relationship between kidney and lung injury and its impact on patient outcome. ABSTRACT |
| Databáze: | OpenAIRE |
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