Follicular helper T lymphocytes (TFH) in health and disease
| Autor: | Patricia Baré, Maria Marta de Elizalde, N. Galassi, Ana Coraglia, Alejandro Malbrán, Maria Noel Badano, Cecilia María Parodi Ramoneda |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Viral Diseases
CIENCIAS MÉDICAS Y DE LA SALUD Helper T lymphocyte AUTOIMMUNITY Inmunología Ciencias de la Salud Disease medicine.disease_cause INTERLEUKIN-21 Autoimmunity purl.org/becyt/ford/3.3 [https] Interleukin 21 CHEMOKINE RECEPTOR 5 Protozoan infection Follicular phase Immunodeficiences Parasitic Diseases medicine Follicular T Lymphocytes PRIMARY IMMUNODEFICIENCES business.industry PROTOZOAN INFECTIONS TFH DEVELOPMENT Germinal center PROGRAMMED CELL DEATH-1 /PROGRAMMED CELL DEATH LIGAND 1 (PDL-1) OR PDL-2 purl.org/becyt/ford/3.1 [https] medicine.disease Otras Ciencias de la Salud Medicina Básica Immunology CHRONIC VIRAL INFECTIONS purl.org/becyt/ford/3 [https] FOLLICULAR HELPER LYMPHOCYTES business |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes (TFH) in this reaction. We shall focus on the regulation of their development and function in health and disease. TFH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper IgM syndrome or X-linked lymphoproliferative disease. Increased numbers of TFH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating TFH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of TFH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies. Fil: Parodi Ramoneda, Cecilia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Badano, Maria Noel. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Coraglia, Ana Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina Fil: Malbrán, Alejandro. Unidad de Alergía, Asma e Inmunología Clínica; Argentina Fil: de Elizalde, Maria Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas ; Argentina |
| Databáze: | OpenAIRE |
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