Bloodstream Infections in Early Postsurgery Liver Transplant: An Analysis of 401 Patients Over 10 Years
| Autor: | Elaine Cristina de Ataide, Raquel Silveira Bello Stucchi, Antonio Luis Eiras Falcão, Ilka de Fátima Santana Ferreira Boin, Desanka Dragosavac, Lucas Amaral Emídio, Felicio Chueiri Neto, Simone Perales, Paulo Osni Leão Perin |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis medicine.medical_treatment Hepatitis C virus Bacteremia Disease Liver transplantation Gram-Positive Bacteria medicine.disease_cause Liver disease Postoperative Complications Drug Resistance Multiple Bacterial Internal medicine Gram-Negative Bacteria Humans Medicine General hospital Survival rate Aged Retrospective Studies Transplantation business.industry Incidence Fungi Middle Aged medicine.disease Liver Transplantation Multiple drug resistance Female Surgery business |
| Zdroj: | Transplantation Proceedings. 51:1972-1977 |
| ISSN: | 0041-1345 |
| Popis: | Bloodstream infections are a major factor contributing to morbidity and mortality following liver transplantation. The increasing occurrence of multidrug-resistant bloodstream infections represents a challenge for the prevention and treatment of those infections. The aim of this study was to evaluate the occurrence and microbiological profile of bloodstream infections during the early postoperative period (from day 0 to day 60) in patients undergoing liver transplantation from January 2005 to June 2016 at the State University of Campinas General Hospital. A total of 401 patients who underwent liver transplantation during this period were included in the study. The most common cause of liver disease was hepatitis C virus cirrhosis (34.01%), followed by alcoholic disease (16.24%). A total of 103 patients had 139 microbiologically proven bloodstream infections. Gram-negative bacteria were isolated in 63.31% of the cases, gram-positive bacteria in 28.78%, and fungi in 7.91%. Fifty-six infections (43.75%) were multidrug-resistant bacteria, and 72 (56.25%) were not. There was no linear trend concerning the occurrence of multidrug-resistant organisms throughout the study period. Patients with multidrug-resistant bloodstream infections had a significantly lower survival rate than those with no bloodstream infections and those with non–multidrug-resistant bloodstream infections. In conclusion, the occurrence of bloodstream infections during the early postoperative period was still high compared with other profile patients, as well as the rates of multidrug-resistant organisms. Even though the occurrence of multidrug resistance has been stable for the past decade, the lower survival rates associated with that condition and the challenge related to its treatment are of major concern. |
| Databáze: | OpenAIRE |
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