Formulation and Characterization of a 3D-Printed Cryptotanshinone-Loaded Niosomal Hydrogel for Topical Therapy of Acne
| Autor: | Wang Zhuxian, Lidong Weng, Chen Tingting, Wu Wenfeng, Li Liu, Du Qunqun, Qiang Liu, Xue Yaqi, Xiang Shijian, Hongxia Zhu, Ruan Shifa, Huoji Chen, Shen Qun, Cuiping Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Skin Absorption Pharmaceutical Science 02 engineering and technology Aquatic Science medicine.disease_cause Administration Cutaneous 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems In vivo Drug Discovery Acne Vulgaris medicine Stratum corneum Animals Niosome Particle Size Ecology Evolution Behavior and Systematics Acne Transdermal Skin Ecology Chemistry Hydrogels General Medicine Penetration (firestop) Permeation Phenanthrenes 021001 nanoscience & nanotechnology medicine.disease Rats medicine.anatomical_structure Liposomes Printing Three-Dimensional Irritation 0210 nano-technology Agronomy and Crop Science Biomedical engineering |
| Zdroj: | AAPS PharmSciTech. 21(5) |
| ISSN: | 1530-9932 |
| Popis: | Cryptotanshinone (CPT) is an efficacious acne treatment, while niosomal hydrogel is a known effective topical drug delivery system that produces a minimal amount of irritation. Three-dimensional (3D) printing technologies have the potential to improve the field of personalized acne treatment. Therefore, this study endeavored to develop a 3D-printed niosomal hydrogel (3DP-NH) containing CPT as a topical delivery system for acne therapy. Specifically, CPT-loaded niosomes were prepared using a reverse phase evaporation method, and the formulation was optimized using a response surface methodology. In vitro characterization showed that optimized CPT-loaded niosomes were below 150 nm in size with an entrapment efficiency of between 67 and 71%. The CPT-loaded niosomes were added in a dropwise manner into the hydrogel to formulate CPT-loaded niosomal hydrogel (CPT-NH), which was then printed as 3DP-CPT-NH with specific drug dose, shape, and size using an extrusion-based 3D printer. The in vitro release behavior of 3DP-CPT-NH was found to follow the Korsmeyer-Peppas model. Permeation and deposition experiments showed significantly higher rates of transdermal flux, Q24, and CPT deposition (p |
| Databáze: | OpenAIRE |
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