Correction: Incidence of dengue illness in Mexican people aged 6 months to 50 years old: A prospective cohort study conducted in Jalisco

Autor: Gloria Huerta, Melanie de Boer, Adrienne Guignard, Rodrigo DeAntonio, Gabriela Ibarra-Nieto, Silvia Damaso, Gerardo Amaya-Tapia
Rok vydání: 2021
Předmět:
Male
RNA viruses
Viral Diseases
Pediatrics
Epidemiology
Physiology
Dengue virus
Pathology and Laboratory Medicine
medicine.disease_cause
Vascular Medicine
Biochemistry
Geographical locations
Dengue Fever
Dengue fever
Dengue
Medical Conditions
Seroepidemiologic Studies
Immune Physiology
Medicine and Health Sciences
Cumulative incidence
Enzyme-Linked Immunoassays
Child
Prospective cohort study
Immune System Proteins
Multidisciplinary
Incidence
Incidence (epidemiology)
Middle Aged
Infectious Diseases
Medical Microbiology
Child
Preschool
Viral Pathogens
Viruses
Medicine
Female
Pathogens
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Adolescent
Infectious Disease Control
Science
Immunology
Hemorrhage
Disease Surveillance
Research and Analysis Methods
Microbiology
Antibodies
Signs and Symptoms
medicine
Humans
Seroprevalence
Immunoassays
Microbial Pathogens
Mexico
Biology and life sciences
Flaviviruses
business.industry
Organisms
Correction
Infant
Proteins
Dengue Virus
Tropical Diseases
medicine.disease
Infectious Disease Surveillance
North America
Immunologic Techniques
People and places
Clinical Medicine
Serostatus
business
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0250253 (2021)
ISSN: 1932-6203
Popis: Background and objectives The burden of dengue virus (DENV), a mosquito-borne pathogen, remains difficult to assess due to misdiagnosis and underreporting. Moreover, the large proportion of asymptomatic dengue cases impairs comprehensive assessment of its epidemiology even where effective surveillance systems are in place. We conducted a prospective community-based study to assess the incidence of symptomatic dengue cases in Zapopan and neighboring municipalities in the state of Jalisco, Mexico. Methods Healthy subjects aged 6 months to 50 years living in households located in the Zapopan and neighboring municipalities were enrolled for a 24-month follow-up study (NCT02766088). Serostatus was determined at enrolment and weekly contacts were conducted via phone calls and home visits. Participants had to report any febrile episode lasting for at least two days. Suspected dengue cases were tested by reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), detection of non-structural protein 1 (NS1), anti-DENV immunoglobulin G and M (IgG and IgM) assays. Results A total of 350 individuals from 87 households were enrolled. The overall seroprevalence of anti-DENV IgG at enrolment was 19.4% (95% confidence interval [CI] 14.5–25.6) with the highest seroprevalence rate observed in the adult group. Over the 27-month study period from July 2016 to September 2018, a total of 18 suspected dengue cases were reported. Four cases were confirmed by RT-qPCR and serotyped as DENV-1. A fifth case was confirmed by the NS1 assay. The 13 remaining suspected cases were tested negative by these assays. Based on the 5 virologically confirmed cases, symptomatic dengue incidence proportion of 1.4% (95%CI 0.5–3.8) was estimated. No severe cases or hospitalizations occurred during the study. Conclusion Community-based active surveillance was shown as efficient to detect symptomatic dengue cases. Clinical trial registration NCT02766088.
Databáze: OpenAIRE
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