Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis
| Autor: | Stuart C. Clarke, Mohd Nasir Mohd Desa, Cheng Foh Le, Eddy Seong Guan Cheah, Alex Lister, David W. Cleary |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Serotype medicine.medical_specialty 030106 microbiology Population Distribution (economics) Pneumococcal disease PCV13 Review Disease PCV10 Antimicrobial resistance medicine.disease_cause Vaccine types Diseases of the respiratory system 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus pneumoniae medicine 030212 general & internal medicine education education.field_of_study RC705-779 business.industry Pneumonia medicine.disease National Immunisation Programme Meta-analysis Pneumococcal pneumonia business Vaccine |
| Zdroj: | Pneumonia Pneumonia, Vol 13, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2200-6133 |
| DOI: | 10.1186/s41479-021-00086-7 |
| Popis: | Background Pneumococcal pneumonia is the leading cause of under-five mortality globally. The surveillance of pneumococcal serotypes is therefore vital for informing pneumococcal vaccination policy and programmes. Pneumococcal conjugate vaccines (PCVs) have been available as an option in the private healthcare setting and beginning December 2020, PCV10 was incorporated as part of routine national immunisation programme (NIP) in Malaysia. We searched existing literature on pneumococcal serotype distribution across Malaysia to provide an overall view of this distribution before the implementation of PCV10. Methods Online databases (PubMed, Ovid MEDLINE and Scopus), reference lists of articles identified, and grey literature (Malaysian Ministry of Health website, WHO website) were systematically searched for relevant literature on pneumococcal serotype distribution across Malaysia up to 10th November 2020. No lower date limit was set to maximise the number of target reports returned. Results of serotypes were split by age categories, including ≤5 years, > 5 years and unreported for those that did not specify. Results The search returned 18 relevant results, with a total of 2040 isolates. The most common serotypes across all disease types were 19F (n = 313, 15.3% [95%CI: 13.8–17.0]), 23F (n = 166, 8.1% [95%CI: 7.0–9.4]), 14 (n = 166, 8.1% [95%CI: 7.0–9.4]), 6B (n = 163, 8.0% [95%CI: 6.9–9.2]) and 19A (n = 138, 6.8% [95%CI: 5.8–7.9]). Conclusion Four of the most common serotypes across all isolate sources in Malaysia are covered by PCV10, while PCV13 provides greater serotype coverage in comparison to PCV10. There is still a need for surveillance studies, particularly those investigating serotypes in children under 5 years of age, to monitor vaccine effectiveness and pneumococcal population dynamic following implementation of PCV10 into routine immunisation. |
| Databáze: | OpenAIRE |
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