Enhanced reactivity of amino-modified oligonucleotides by insertion of aromatic residue

Autor:	Maiko Sugino, Yumi Fujinawa, Naoshi Kojima, Muto Isamu, Matsubara Kenichi, Ken Nonaka, Yasuo Komatsu, Akiko Mikami, Eiko Ohtsuka
Rok vydání:	2006
Předmět:	Oligonucleotide Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Oligonucleotides Fluorescence spectrometry Nucleic Acid Hybridization Pharmaceutical Science Chemical modification Biochemistry Chemical synthesis Structure-Activity Relationship Residue (chemistry) Cross-Linking Reagents Drug Discovery Combinatorial Chemistry Techniques Molecular Medicine Amine gas treating Amines Polycyclic Aromatic Hydrocarbons Aliphatic compound Molecular Biology Linker
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 16:5118-5121
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2006.07.027
Popis:	We developed novel amino-modifying reagents, of which an amino group was connected with an aromatic residue by aliphatic linker. It was proved that the insertion of the aromatic residue could increase the reactivity of the amino group on oligonucleotides in comparison with conventional amino-modification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49074c37a67a749c56a172d445c52e65 https://doi.org/10.1016/j.bmcl.2006.07.027 Zobrazit plný text záznamu Full Text from ScienceDirect