Mild Traumatic Brain Injury Decreases Broadband Power in Area CA1
| Autor: | Jaclynn A. Elkind, Akiva S. Cohen, Hannah E. Metheny, Guoxiang Xiong, Rosalia Paterno |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Traumatic brain injury Short Communication Local field potential Hippocampal formation Electroencephalography Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Hippocampus (mythology) CA1 Region Hippocampal Brain Concussion medicine.diagnostic_test Cognition medicine.disease Pathophysiology nervous system diseases Mice Inbred C57BL Electrophysiology 030104 developmental biology nervous system Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 33:1645-1649 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2015.4107 |
| Popis: | Cognitive impairment caused by traumatic brain injury (TBI) can lead to devastating consequences for both patients and their families. The underlying neurological basis for TBI-induced cognitive dysfunction remains unknown. However, many lines of research have implicated the hippocampus in the pathophysiology of TBI. In particular, past research has found that theta oscillations, long thought to be the electrophysiological basis of learning and memory, are decreased in the hippocampus post-TBI. Here, we recorded in vivo electrophysiological activity in the hippocampi of 16 mice, 8 of which had previously undergone a TBI. Consistent with previous data, we found that theta power in the hippocampus was decreased in TBI animals compared to sham controls; however, this effect was driven by changes in broadband power and not theta oscillations. This result suggests that broadband fluctuations in the hippocampal local field potential can be used as an electrophysiological surrogate of abnormal neurological activity post-TBI. |
| Databáze: | OpenAIRE |
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