High urine 1-hydroxypyrene glucuronide concentrations in Linxian, China, an area of high risk for squamous oesophageal cancer
| Autor: | J. A. Tangrea, You-Lin Qiao, Mark J. Roth, S. M. Dawsey, P R Taylor, G.-Q. Wang, S.-H. Cho, Daehee Kang, Nathaniel Rothman, P. T. Strickland |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Pathology Health Toxicology and Mutagenesis Clinical Biochemistry Population Cancer Urine Pah exposure medicine.disease Biochemistry Gastroenterology chemistry.chemical_compound chemistry Epidermoid carcinoma Internal medicine medicine Pyrene 1-hydroxypyrene glucuronide education Carcinogen |
| Zdroj: | Biomarkers. 6:381-386 |
| ISSN: | 1366-5804 1354-750X |
| Popis: | Most squamous cell carcinomas of the oesophagus in low-risk populations are attributable to alcohol and tobacco consumption, but the aetiologic agents in many high-risk populations have yet to be definitively identified. Linxian, China has some of the highest oesophageal cancer rates in the world. Recent studies suggest that an association exists between high-level exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), and the development of oesophageal cancer. The inhabitants of this high-risk region extensively use coal and wood for cooking and heating in unvented stoves, and thus may be exposed to PAHs produced during the incomplete combustion of these fuel sources. High levels of B[a]P were recently detected in staple food samples from Linxian and histopathologic changes that may be associated with PAH exposure have also been identified in oesophagectomy specimens from the region. In an effort to determine whether this high-risk population is exposed to high levels of PAHs, voided urines from non-smokers (n = 22) without occupational exposure were collected and analysed using immunoaffinity chromatography and synchronous fluorescence spectroscopy for 1-hydroxypyrene glucuronide, a PAH metabolite and index biomarker for mixed PAH exposure. The median urine 1-hydroxypyrene glucuronide concentration (2.06 pmol ml(-1)) was equivalent to concentrations detected in current smokers. To the authors' knowledge, this represents the first report of elevated urine 1-hydroxpyrene glucuronide concentrations in Linxian, and the first biologic confirmation that the inhabitants of this rural, non-industrial, high oesophageal cancer risk region are exposed to carcinogenic PAHs. |
| Databáze: | OpenAIRE |
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