Effect of Short Versus Long-Term Steroid on Corneal Haze After Photorefractive Keratectomy: A Randomized, Double-Masked Clinical Trial
| Autor: | Mojgan Pakbin, Mohamadreza Aghamirsalim, Mohammad Pakravan, Akbar Fotouhi, Mehdi Khabazkhoob, Hassan Hashemi, Ebrahim Jafarzadehpur |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures medicine.drug_class Mitomycin medicine.medical_treatment Refraction Ocular Single Center Placebo Photorefractive Keratectomy Young Adult Ophthalmology Myopia medicine Humans Prospective Studies Fluorometholone Dioptre Corneal Haze business.industry eye diseases Photorefractive keratectomy Treatment Outcome Corticosteroid Lasers Excimer sense organs business Densitometry medicine.drug |
| Zdroj: | American Journal of Ophthalmology. 235:211-220 |
| ISSN: | 0002-9394 |
| Popis: | Purpose To compare the effect of duration of fluorometholone 0.1% treatment on corneal haze after photorefractive keratectomy (PRK) with mitomycin C (MMC) 0.02%. Design Prospective, randomized, double-blind, clinical trial. Methods Setting: Single center clinical trial. Study Population: A total of 252 myopic PRK candidates (252 eyes) aged 21 to 40 years with a mean spherical equivalent (SE) of ≤ 6 diopters (D) were randomized to receive one of the three corticosteroid regimens after PRK (group A = 1 month followed by 2-month placebo, group B = 2 months followed by 1-month placebo and group C = 3 months). Main Outcome Measures: Corneal haze incidence, subjective SE, uncorrected distance visual acuity (UDVA), and corneal densitometry. Results The corneal haze incidence (grade ≥ 1) at 12 months was 1.35% (1/74 eyes) in group A and 0% in the other two groups. The mean anterior corneal densitometry (grayscale unit) was 21.19 ± 2.07, 21.09 ± 2.19, and 21.31 ± 2.21 in group A, B and C, respectively. The mean SE was 0 ± 0.09, 0 ± 0.11, and 0 ± 0.10 and UDVA (decimal) was 1 ± 0, 1 ± 0.01, and 1 ± 0 in group A, B and C, respectively. During 1-year follow-up, no statistically significant difference was observed in mean SE (p = 0.158), UDVA (p = 0.343) and anterior corneal densitometry (p = 0.109) at any stage between the study groups. Conclusions Long-term topical corticosteroids are not necessary following PRK with MMC for moderate myopia. |
| Databáze: | OpenAIRE |
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