The effect of female age on the likelihood of a live birth from one in‐vitro fertilisation treatment

Autor: Robert P.S. Jansen
Rok vydání: 2003
Předmět:
Zdroj: Medical Journal of Australia. 178:258-261
ISSN: 1326-5377
0025-729X
Popis: Objective: To determine the chance of at least one live birth from one round of in-vitro fertilisation (IVF) treatment and the effect of the woman's age on that likelihood. Design: Retrospective analysis of outcomes from IVF treatment that did not involve donated gametes, but which included embryos cryopreserved in the retrieval cycle. Setting and patients: All IVF patients (median age, 36 years; range, 22-48 years) who attended a private IVF clinic in Sydney for an egg retrieval between 1 January 1998 and 31 December 1998, and had embryo placements (fresh and cryostored) performed up to 30 June 2001. Main outcome measure: Independently audited live births surviving the neonatal period. Results: 565 women had 648 egg retrievals during the period. The age of peak utilisation of IVF was 39 years. For women aged 34 years or less, the chance of a live birth from one round of egg retrieval and IVF treatment was 52.4% (95% Cl, 47%-59%). For women aged 35-44 years, there was a linear decline in the live birth rate, and no babies were born from retrievals at age 45 years and over. There was an age-dependent rise in the frequency of miscarriages, from 10.5% (95% Cl, 5%-18%) for women under 35 years, to 16.1% (95% Cl, 9%-25%) for those 35-39 years, and 42.9% [95% Cl, 24%-63%] for those over 40 years (P
Databáze: OpenAIRE
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